Detection of epigenomic network community oncomarkers
نویسندگان
چکیده
منابع مشابه
Detection of Epigenomic Network Community Oncomarkers
In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a gene-regulatory pattern, and hence provides a means by which to assess genom...
متن کاملDetection of Epigenomic Network Community
In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a gene-regulatory pattern, and hence provides a means by which to assess genom...
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Epigenetic processes--including DNA methylation--are increasingly seen as having a fundamental role in chronic diseases like cancer. DNA methylation patterns offer a route to develop prognostic measures based directly on DNA measurements, rather than less-stable RNA measurements. A novel DNA methylation-based measure of the co-ordinated interactive behaviour of genes is developed, in a network ...
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Community structure is largely regarded as an intrinsic property of complex real-world networks. However, recent studies reveal that networks comprise even more sophisticated modules than classical cohesive communities. More precisely, real-world networks can also be naturally partitioned according to common patterns of connections between the nodes. Recently, a propagation based algorithm has ...
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Community detection in complex network has become a vital step to understand the structure and dynamics of networks in various fields. However, traditional node clustering and relatively new proposed link clustering methods have inherent drawbacks to discover overlapping communities. Node clustering is inadequate to capture the pervasive overlaps, while link clustering is often criticized due t...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2016
ISSN: 1932-6157
DOI: 10.1214/16-aoas939